ARYL ACID PYRIMIDINYL METHYL AMIDES, PYRIDAZINYL METHYL AMIDES AND RELATED COMPOUNDS

摘要

The invention provides compounds of Formula (I) that bind to GABAA receptors . In the above formula, variables are defined herein. Such compounds may be us ed to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals, and livestock animals. Compounds provided herein may be administered alone or in combinati on with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorder s are provided, as are methods for using such ligands for detecting GABAA receptors (e.g., receptor localization studies).