发明名称 Substituted pyrroloquinolines and pyridoquinolines as serotomin agonists and antagonists.
摘要 The present invention is directed to certain novel compounds represented by structural Formula (I)or pharmaceutically acceptable salt forms thereof, wherein is R<1>, R<6a>, R<6b>, R<7>, R<8>, R<9>, X, b, m, and n are described herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including obesity, anxiety, depression, psychosis, schizophrenia, sleep disorders, sexual disorders, migraine, conditions associated with cephalic pain, social phobias, and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.
申请公布号 ZA200304304(B) 申请公布日期 2004.09.02
申请号 ZA20030004304 申请日期 2003.06.02
申请人 BRISTOL-MYERS SQUIBB COMPANY 发明人 JOHN M. FEVIG;TAEKYU LEE;JOSEPH CACCIOLA;IAN S. MITCHELL;WENTING CHEN
分类号 C07D471/14;A61K;A61K31/437;A61K31/4375;A61K31/4745;A61K31/553;A61P;A61P1/14;A61P3/04;A61P15/00;A61P25/00;A61P25/04;A61P25/18;A61P25/20;A61P25/22;A61P25/24;C07D;C07D209/00;C07D221/00;C07D471/16;C07D498/14;C07D498/16;C07D513/16 主分类号 C07D471/14
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