Continuous cyanoalkylation process of compounds having one or more NH functions

摘要

Cyanoalkylation of ammonia or organic compounds containing one or more NH functions, by reaction with a carbonyl compound and hydrocyanic acid in a solvent, is carried out in two stages comprising a first stage (i) at a temperature (T1) below the boiling point of the reaction mixture, and a second stage (i) at a temperature (T2) below 150 degrees C. Cyanoalkylation of ammonia or organic compounds containing one or more NH functions, by reaction with a carbonyl compound and hydrocyanic acid (each at 1 mol per NH function to be converted) in a solvent, is carried out in two stages comprising a first stage (i) at a temperature (T1) below the boiling point of the reaction mixture, carried out until the degree of HCN conversion is at least 60% and a second stage (i) at a temperature (T2) below 150degreesC, carried out until the degree of HCN conversion is at least 90%. An Independent claim is included for alpha -cyanoalkylamines (I) obtained by the process.