发明名称 |
Methods of homing molecules to lung using membrane dipeptidase |
摘要 |
The present invention provides a method of identifying a membrane dipeptidase (MDP)-binding homing molecule that selectively homes to lung endothelium. The method includes the steps of contacting MDP with one or more molecules; and determining specific binding of a molecule to the MDP, where the presence of specific binding identifies the molecule as a MDP-binding homing molecule that selectively homes to lung endothelium. Such MDP-binding homing molecules can be linked to a moiety and, when administered to a subject as a conjugate, can selectively direct the moiety to lung endothelium in the subject.
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申请公布号 |
US6784153(B1) |
申请公布日期 |
2004.08.31 |
申请号 |
US20000676475 |
申请日期 |
2000.09.29 |
申请人 |
THE BURNHAM INSTITUTE |
发明人 |
RAJOTTE DANIEL;PASQUALINI RENATA;RUOSLAHTI ERKKI |
分类号 |
C12N15/09;A61K31/195;A61K38/00;A61K45/00;A61K47/48;A61K48/00;A61P35/00;A61P35/04;A61P43/00;C07C233/46;C07K7/06;C07K7/08;C07K14/705;(IPC1-7):A61K38/00;A61K31/215;C12Q1/37 |
主分类号 |
C12N15/09 |
代理机构 |
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主权项 |
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地址 |
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