发明名称 |
PREPARATION OF MICROPARTICLES, COMPOSITIONS COMPRISING THEM AND USES THEREOF |
摘要 |
Preparation of biocompatible, biodegradable microparticles, comprising contacting microparticles having a polymer matrix containing an active agent and an organic solvent with an aqueous solvent system, in which the organic solvent content of the microparticles is reduced to 2% or less of the weight of the microparticles; so that the solvent system satisfies the conditions: (a) that it is at elevated temperature during at least part of the contact time with the microparticles; and/or (b) that it comprises water and a water-miscible solvent for the organic solvent, finally recovering the microparticles from the system. |
申请公布号 |
IL126509(A) |
申请公布日期 |
2004.08.31 |
申请号 |
IL19970126509 |
申请日期 |
1997.05.06 |
申请人 |
JANSSEN PHARMACEUTICA N.V.;ALKERMES CONTROLLED THERAPEUTICS INC. |
发明人 |
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分类号 |
A61K9/56;A61K9/14;A61K9/16;A61K9/50;A61K9/58;A61K31/505;A61K31/517;A61K31/519;A61K31/529;A61K47/30;A61K47/34;B01J13/04;B01J13/06;B29B9/00;(IPC1-7):A61K9/16 |
主分类号 |
A61K9/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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