发明名称 |
UTILIZACAO DE INIBIDORES DE HISTONA-DESCARBOXILASE PARA O TRATAMENTO DE FIBROSE |
摘要 |
The invention relates to a pharmaceutical composition for the treatment of fibrosis. According to the invention it was surprisingly found that submicromolar concentrations of a histone deacetylase inhibitor and in particular of trichostatin A strongly inhibit three main features of myofibroblastic differentiation of cultured hepatic stellate cells and of skin fibroblasts: (1) synthesis of collagens type I and III, the predominant collagens in fibrosis of liver and other organs; (2) cellular proliferation; and (3) expression of smooth muscle alpha -actin, a marker for activated myofibroblasts. These results indicate that trichostatin A is a potent antifibrogenic agent, totally different from any other therapeutic compounds previously described. |
申请公布号 |
PT827743(E) |
申请公布日期 |
2004.08.31 |
申请号 |
PT19970202644T |
申请日期 |
1997.08.29 |
申请人 |
VRIJE UNIVERSITEIT BRUSSEL |
发明人 |
ALBERT EMMANUEL CORNEILLE GEERTS;TOSHIRO NIKI |
分类号 |
A61K9/06;A61K31/00;A61K31/165;A61K31/19;A61K38/12;A61K45/00;A61P1/16;A61P17/00;A61P43/00;(IPC1-7):A61K31/165;A61P17/02 |
主分类号 |
A61K9/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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