发明名称 |
Treatment of heart rhythm disturbances with N6-substituted-5'-(N-substituted) carboxamidoadenosines |
摘要 |
The present invention discloses a method for treating heart rhythm disturbances in a mammal in need thereof by the administration of N<6>-substituted-5'(N-substituted)carboxamidoadenosines. More particularly, the invention is directed to a method for treatment of heart rhythm disturbances in a mammal that would benefit from the induction of negative dromotropic and/or negative chronotropic actions, comprising the administration to said mammal an effective amount of a compound of the Formula:or a pharmaceutically acceptable salt or ester thereof; whereinR1 is C3-7 secondary alkyl, or C3-8 cycloalkyl; andR2 is C1-4 alkyl or C3-5 cycloalkylThe invention is also directed to novel dosage forms comprising said compounds.
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申请公布号 |
US6784165(B1) |
申请公布日期 |
2004.08.31 |
申请号 |
US20000713307 |
申请日期 |
2000.11.16 |
申请人 |
ADERIS PHARMACEUTICALS, INC. |
发明人 |
MARTIN PAULINE L. |
分类号 |
A61K31/70;(IPC1-7):A61K31/70;C07H19/167 |
主分类号 |
A61K31/70 |
代理机构 |
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