| 发明名称 |
Stable complexes of poorly soluble compounds |
| 摘要 |
<p>Stable water-insoluble complexes of poorly soluble compounds molecularly dispersed in water-insoluble ionic polymers are disclosed. Useful insoluble ionic polymers have a molecular weight greater than about 80,000 D and a glass transition temperature equal to or greater than about 50 DEG . The compounds are microprecipitated in the ionic polymers in amorphous form. The complexes according to the present invention significantly increase the bioavailability of poorly soluble therapeutically active compounds.</p> |
| 申请公布号 |
SI0988863(T1) |
申请公布日期 |
2004.08.31 |
| 申请号 |
SI19990030573T |
申请日期 |
1999.09.13 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
ALBANO ANTONIO A.;PHUAPRADIT WANTANEE;SANDHU HARPREET K.;SHAH NAVNIT HARGOVINDAS |
| 分类号 |
C07D239/60;A61K9/14;A61K9/20;A61K9/48;A61K31/15;A61K31/166;A61K31/18;A61K31/216;A61K31/404;A61K31/496;A61K31/515;A61K31/5517;A61K45/08;A61K47/30;A61K47/32;A61K47/38;A61K47/48;C07D403/14;C07D487/04;(IPC1-7):A61K47/32;A61K31/551 |
主分类号 |
C07D239/60 |
| 代理机构 |
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