HETEROCYCLYLALKYLPIPERIDINE DERIVATIVES, THEIR PRODUCTION AND COMPOSITIONS CONTAINING THEREOF

摘要

The invention concerns heterocyclylalkyl piperidine derivatives of general formula wherein X1, X2, X3, X4 and X5 are >C-R1' to >C-R5', or one or most represents N; R2 is COOH, alkyloxycarbonyl, cycloalkyloxycarbonyl, CN, -CONRaRb or R2 is -CF2-Rc, -C(CH3)2-Rc, -CO-Rc, -CHOH-Rc, -C(cycloalkyl)-Rc or -CH=CH-Rc; R3 is phenyl, heterocyclyl,alk-R3o, Y represents >CH-Re or a difluoromethylene, carbonyl, hydroxyiminomethylene, alkyloxyiminomethylene, cycloalkyloxyiminomethylene radical, or a cycloalkylene-1,1 radical, and n = 0 to 4 provided that the radicals or phenyl or heterocyclyl portions mentioned above can optionally be substituted in the enantiomeric or diastereoisomeric forms or mixtures thereof, and/or as the case may be in their syn or anti form or mixture thereof and their salts.