METHOD FOR PRODUCING LHRH-PEPTIDE SALTS, THEIR USE, AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE PEPTIDE SALTS

摘要

A method for producing peptide salts, including reacting an acid addition salt of a basic starting peptide in the presence of a diluent in a mixed bed ion exchanger, with a mixture of an acid and a basic ion exchanger during the formation of a free basic peptide, and then separating the ion exchanger and then the free basic peptide, with an inorganic or organic acid, and then forming the desired acid addition salt of the peptide, and removing the diluent.