| 摘要 |
THE PRESENT INVENTION CONCERNS THE COMPOUNDS OF FORMULA ( FORMULA 1 ) THE N-OXIDE FORMS, THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS AND STEREOCHEMICALLY ISOMERIC FORMS THEREOF, WHEREIN X IS O OR S; N IS 2, 3, 4 OR 5; R1 IS HYDROGEN, C1-6ALKYL, C1-6ALKYLOXY OR HALO; R2 IS HYDROGEN, C1-6ALKYL, PHENYL, PHENYLC1-6ALKYL OR PHENYLCARBONYL; R3 AND R4 EACH INDEPENDENTLY ARE SELECTED FROM HYDROGEN, HALO, NITRO, C1-6ALKYL, C1-6ALKYLOXY, HALOC1-6ALKYL, AMINOSULFONYL, MONO-OR DI(C1-4ALKYL)AMINOSULFONYL; OR R3 AND R4 MAY ALSO BE TAKEN TOGETHER TO FORM A BIVALENT RADICAL OF FORMULA -CH=CH-CH=CH-; IT FURTHER RELATES TO PROCESSES FOR THEIR PREPARATION, COMPOSITIONS COMPRISING THEM AS WELL AS THEIR USE AS A MEDICINE; COMPOUNDS OF FORMULA (I) CONTAINING A RADIOACTIVE ISOTOPE; A PROCESS OF MARKING DOPAMINE D4 RECEPTOR SITES; AND A PROCESS FOR IMAGING AN ORGAN ARE DISCLOSED.
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