A levetiracetam alone or in combination with a compound inducing neural inhibition mediated by the GABA receptors for treatment of chronic pain, bipolar disorder, mania and migraine

摘要

Levetiracetam is used in the manufacture of a medicament for the treatment of bipolar disorders, mania, migraine and chronic or neuropathic pain. Also described is a pharmaceutical composition comprising levetiracetam and at least one compound inducing neural inhibition mediated by the GABAA receptor. Preferably the compound is selected from benzodiazepines, 1,4 benzodiazepines, 1,5 benzodiazepines, barbiturates, steroids, valporate, vigabatrin and tiagabine. The composition can be used in the manufacture of a medicament for the treatment of epilepsy, alcohol withdrawal, tremor, bipolar disorder, mania, obsessive compulsive disorder, panic disorder, anxiety, anxiety disorders, depression, migraine, headache, pain disorders, ischemia and head trauma.