Pyridinylimidazoles

摘要

Disclosed herein are pyridyl substituted imidazoles of formula (I) and pharmaceutically acceptable salts thereof, which are inhibitors of the transforming growth factor,("TGF")-b signaling pathway, in particular, the phosphorylation of smad2 or smad3 by the type I or activin-like kinase ("ALK")-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway, wherein R1, R2 and R3 represent various functional groups as defined in the specification, and one of X1 and X2 is N and the other is NR10.