| 摘要 |
FIELD: biochemistry, medicine, pharmacy. ^ SUBSTANCE: invention relates to preparing HMG-CoA-reductase inhibitor by displacement chromatography method. Inhibitor is taken among the group consisting of lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin and fluvastatin, their derivatives and analogues that are used as anti-hypercholesterolemic agents. The purity degree is the important factor in preparing the safety and effective medicinal agent, especially, if pharmaceutical preparation is used for a long time in treatment or prophylaxis of plasma blood high cholesterol level. Invention provides preparing HMG-CoA-reductase inhibitor with the high purity degree by HPLC data that enhance 99.7%, with high yield, reduced consumptions and suitable chemical balance. ^ EFFECT: improved preparing method. ^ 27 cl, 14 ex |
