| 摘要 |
FIELD: organic chemistry, medicine, pharmacy. ^ SUBSTANCE: invention relates to new compounds that can be used in medicine as hypolipidemic or anti-hyperglycaemic agents. Invention describes beta-aryl-alpha-hydroxy-substituted alkylcarboxylic acids of the formula (I): ^ ^ wherein R1, R2, R3 and R4 can be similar or different and represent hydrogen atom, hydroxy-group, (C1-C3)-alkyl; cycle A condensed with cycle comprising X and nitrogen atom (N) represents 6-membered aromatic cyclic structure comprising carbon atoms; X represents a heteroatom taken among oxygen and sulfur atoms; Ar represents bivalent phenylene, naphthylene or benzofuranyl; R5 represents hydrogen atom; R6 represents hydrogen atom; or R6 forms a bond in common with R5; R7 represents hydrogen atom or optionally substituted linear or branched (C1-C16)-alkyl; R8 represents hydrogen atom or optionally substituted or branched (C1-C16)-alkyl; Y represents oxygen atom or NR10 wherein R10 represents hydrogen atom, phenyl, hydroxy-(C1-C16)-alkyl; n is a whole number in the range 1-4; m = 0 or 1, or its pharmaceutically acceptable salts or pharmaceutically acceptable solvates. Also, invention describes intermediate compounds, methods for their preparing, methods for preparing compounds of the formula (I), pharmaceutical composition based on compounds of the formula (I), methods for treatment and prophylaxis of diseases based on new compounds. Invention provides preparing new compounds eliciting useful biological properties. ^ EFFECT: improved preparing method, valuable medicinal properties of compounds. ^ 31 cl, 23 ex |
