发明名称 |
Pharmaceutical tablet system that floats on gastric fluid for multipulse release of active substance and respective processes of producing same and a cup-shaped envelope of same |
摘要 |
A tablet system for prolonged floating in or on gastric fluid for releasing therein pharmaceutically active substances in an alternate succession of substance release and no-release periods is made up of a multilayered core placed in a cup-shaped envelope. The core is made up of release layers and no-release layers devoid of pharmaceutically active substance, superposed in alternate succession. The cup-shaped envelope covers bottom and side surfaces of the core while leaving exposed an upper surface of the core. The cup-shaped envelope provides for buoyancy by being formed of a compression-sintered mixture comprising hydrophobic material and inert powdered filler. The hydrophobic material is composed of fatty and/or waxy material capable of being sintered by compression and whose bulk density is lower than gastric fluid density. The powdered filler has a loose powder density that is lower than gastric fluid density.
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申请公布号 |
US2004166161(A1) |
申请公布日期 |
2004.08.26 |
申请号 |
US20040473055 |
申请日期 |
2004.03.30 |
申请人 |
GRENIER PASCAL;RICCHI ELISABETH;QUINTON JACQUES;VERGNAULT GUY |
发明人 |
GRENIER PASCAL;RICCHI ELISABETH;QUINTON JACQUES;VERGNAULT GUY |
分类号 |
A61K9/22;A61K9/00;A61K9/20;(IPC1-7):A61K9/24 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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