AMINOTERMINAL VERKÜRZTES MCP-2 ALS CHEMOKIN ANTAGONIST

摘要

The present invention relates to amino-terminally truncated RANTES, lacking NH2-terminal amino acids corresponding to amino acid residues 1, 1-2, 1-3 or 1-4 of the naturally-occurring RANTES and having chemokine antagonistic activity, as well as cDNA sequences encoding them, their use in therapy and/or in diagnosis of the diseases, in which an antagonistic activity of the chemokine effects is required, and pharmaceutical compositions comprising them, and the use of CD26/DPP IV in the therapy and/or diagnosis of the diseases in which an antagonistic activity of the chemokine effects is required.