USES OF CIRCADIAN GENE mPER2

摘要

Data presented herein provide a molecular mechanism for circadian gene mPer2 in DNA damage response and tumor suppression in vivo. Mice deficient in mPer2 gene display neoplastic phenotypes. These mice are deficient in p53-mediated apoptosis in thymocytes and have increased tumor occurrences after gamma-radiation. Core circadian genes are induced by -gamma -radiation in wild-type mice but not in mPer2 mutant mice.Temporal expression of genes involved in cell cycle regulation and tumor suppression, such as c-Myc, Cyclin D1, Cyclin A, Mdm2 and Gadd45alpha is dependent on mPER2 in vivo