RNA INTERFERENCE MEDIATED INHIBITION OF TYPE 1 INSULIN-LIKE GROWTH FACTOR RECEPTOR (IGF-1R)

摘要

The present invention concerns methods and reagents useful modulating type 1 insulin-growth factor receptor (IGF-1R) gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against IGF-1R gene expression and/or activity. The small nucleic acid molecules are useful in the diagnosis and treatment of cancer, aging, and aging related disease, proliferative disease, autoimmune disease, and any other disease or condition that responds to modulation of IGF-1R expression or activity.