SYNTHESIS OF VICINAL DIFLUORO AROMATIC COMPOUND AND INTERMEDIATE THEREOF

摘要

PROBLEM TO BE SOLVED: To provide a method of preparing vicinal difluoro aromatic compounds in high yield. SOLUTION: The vicinal difluoro aromatic compounds and intermediates thereof are produced in high yield from hydroxy aromatic compounds using various bases. A method for making a tetrafluoro derivative of a halogen substituted aromatic compound. The method for making vicinal difluoro halogenated aromatic compounds comprises reacting the tetrafluoro derivative with a reducing agent in the presence of a base for a reaction time sufficient to form the vicinal difluoro halogenated aromatic compound containing two vicinal fluorine substituents and at least one additional halogen substituent, of a halogen substituted aromatic compound, wherein the tetrafluoro derivatives have two fluorine atoms on each adjacent carbon atoms and at least one additional halogen substituent and the reducing agent is used in an effective amount sufficient to obtain at least one additional halogen substituent. COPYRIGHT: (C)2004,JPO&NCIPI