| 摘要 |
Proteins capable of phosphorylating Elk1 and/or activating a kinase which phosphorylates Elk1, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of MAP kinase cascade are provided. Using the plasmids pFR-Luc and pFA2-Elk1, the cDNA encoding a protein capable of phosphorylating Elk1 and/or activating a kinase wich phosphorylates Elk1 was cloned from the cDNA library constructed from human peripheral blood monocytes, and the cDNA sequence and the deduced amino acid sequence were determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting an action of Elk1 phosphorylation and/or an action of activation of kinase which phosphorylates Elk1. |
