FATE DETERMINATION BY HES 1 IN HEMATOPOIETIC STEM-PROGENITOR CELLS AND USES THEREOF

摘要

The invention is based at least in part on the discovery that overexpression of a transcription factor, Hes l promotes the differentiation of hematopoietic stem cells (HSCs) to various cell types, including but not limited to monocyte-macrophages and dendritic cells. Additionally, modulating the expression of Hes l so that Hes l is over- or under­expressed appears to promote the differentiation of HSCs to neurons or glial cells, respectively. Thus, the present invention features methods of differentiating isolated hematopoietic stem cells, that were isolated from either bone marrow (BM), cord blood (CB), peripheral blood (PBSC) or non-mobilized blood.