The present invention relates to the field of immunology. The invention identifies determinants on staphylococcal enterotoxin B (SEB) able to evoke an immune response. In particular the invention is concerned with the identification of epitopes for T-cells in SEB. The invention relates furthermore to T-cell epitope peptides derived from SEB by means of which it is possible to create modified SEB variants with reduced immunogenicity.
申请公布号
WO2004018684(A3)
申请公布日期
2004.08.26
申请号
WO2003EP09116
申请日期
2003.08.18
申请人
MERCK PATENT GMBH;CARR, FRANCIS, J.;BAKER, MATTHEW;CARTER, GRAHAM