发明名称 |
PROCESS FOR PROMOTING GRAFT ACCEPTANCE BY DEPLETION OF HEMATOPOIETIC STEM CELLS |
摘要 |
Therapeutic compositions and methods for modulating the immune system for promoting acceptance of a graft and for treating a hematologic malignancy in the absence of myeloablative therapies are disclosed. The described methodology includes the step of depleting and/or inactivating the hematopoietic stem cells of the recipient using a therapeutic composition comprising at least one antibody specific for depleting and/or inactivating hematopoietic stem cells while maintaining mature blood cells, preferably the antibody selectively depletes and/or inactivates primitive hematopoietic stem cells. The therapeutic composition preferably is administered prior to the administration of bone marrow, mobilized peripheral hematopoietic stem cells, or donor leucocytes. |
申请公布号 |
WO2004002425(A3) |
申请公布日期 |
2004.08.26 |
申请号 |
WO2003US20520 |
申请日期 |
2003.06.27 |
申请人 |
BIO TRANSPLANT, INC. |
发明人 |
DOWN, JULIAN, D.;WHITE-SCHARF, MARY, E. |
分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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