VETERINARY FORMULATION FOR ADMINISTRATION OF A WATER9INSOLUBLE DRUG TO A TARGET ANIMAL THROUGH A WATER DISTRIBUTION SYSTEM

摘要

1. A method of preparing a veterinary composition comprising a water-insoluble active compound suitable for administering to a target animal through a water distribution system, comprising mixing the active compound with a water-immiscible liquid in such a manner that the mixture of active compound and water-immiscible liquid has a density between 0.85 and 1.2, and suspending said mixture in an aqueous carrier. 2. A method according to claim 1, in which said active compound comprises one or more anthelmintics. 3. A method according to claim 2, in which said anthelmintics comprise a benzimidazole or a pro-benzimidazole. 4. A method according to claim 3, in which said anthelmintics is flubendazole. 5. A method according to any one of claims 1-4, in which the active compound and the water-immiscible liquid are used in a weight ratio between 10: 90 and 75: 25. 6. A method according to any one of claims 1-5, in which either the active compound or the water-immiscible liquid has a lower density than water and the other has a higher density than water. 7. A method according to any one of claims 1-6, in which said mixture or the suspension thereof in the aqueous carrier comprises one or more stabilising agents belonging to the group of emulsifiers, surfactants, thickeners, anti-oxidants and antimicrobials. 8. A method according to any one of claims 1-7, in which said water-immiscible liquid is a vegetable oil. 9. A method according to any one of claims 1-8, in which the average particle size of the active compound is between 1 and 30 mkm. 10. A suspoemulsion suitable, optionally after dilution, for administering a veterinarily active compound to a target animal through a water distribution system, comprising a homogeneous suspension in water of a mixture of the active compound and a water immiscible liquid, said mixture having a density between 0.85 and 1.2. 11. A suspoemulsion according to claim 9, comprising one or more of the following features: a) the active compound and the water-immiscible liquid are used in a weight ratio between 10: 90 and 75: 25; b) the active compound is a benzimidazole anthelmintic; c) the water-immiscible liquid is a vegetable oil; d) the suspoemulsion comprises one or more stabilising agents selected from emulsifiers, surfactants, thickeners, anti-oxidants and anti-microbials; e) the weight ratio between said mixture of active compound a water-immiscible liquid and said water is between 80: 20 and 10: 90; f) the density of the mixture of active compound and water-immiscible liquid is between 0.95 and 1.05. 12. A suspoemulsion according to claim 11, in which said benzimidazole anthelmintics is selected from the group of flubendazole, fenbendazole, mebendazole, oxfendazole, albendazole, cambendazole, parbendazole, oxibendazole and cyclobendazole. 13. A suspoemulsion according to claim 12, in which said benzimidazole anthelmintics is flubendazole.