发明名称 |
Use of Idebenone for the preservation of compositions |
摘要 |
The use of idebenone (I) (i.e. 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone) or its derivative (I') is claimed in cosmetic or topical dermatological preparations. ACTIVITY : Dermatological; antiinflammatory; antiallergic; immunosuppressive. MECHANISM OF ACTION : Antioxidant; radical scavenger; apoptosis inhibitor. In macrophage-LDL antioxidant tests (I) at 10 MicroM completely prevented lipid peroxide formation after 8 and 24 hours, and was markedly more effective than ascorbic acid at 50 mu M, alpha -tocopherol at 100 mu M or glutathione at 50 mu M. |
申请公布号 |
EP1449511(A1) |
申请公布日期 |
2004.08.25 |
申请号 |
EP20040010332 |
申请日期 |
2000.05.19 |
申请人 |
NEUDECKER, BIRGIT;WIELAND, EBERHARD;DIEDRICH, FALKO |
发明人 |
NEUDECKER, BIRGIT;WIELAND, EBERHARD;DIEDRICH, FALKO |
分类号 |
A61K8/30;A61K8/35;A01N25/00;A61K;A61K8/00;A61K8/46;A61K8/67;A61K8/72;A61K8/73;A61K31/015;A61K31/07;A61K31/12;A61K31/122;A61K31/203;A61K31/255;A61K31/355;A61K31/375;A61K31/728;A61K31/74;A61P17/00;A61P17/16;A61P43/00;A61Q1/00;A61Q1/04;A61Q1/06;A61Q5/00;A61Q17/00;A61Q17/04;A61Q19/00;A61Q19/08 |
主分类号 |
A61K8/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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