| 发明名称 |
Protein Kinase C Inhibitors |
| 摘要 |
<p>The present invention discloses compounds that are highly isozyme selective protein kinase C beta-1 and beta-2 isozyme inhibitors. Accordingly, the present invention provides a method of selectively inhibiting protein kinase C isozymes beta-1, and beta-2. As isozyme selective inhibitors of beta-1 and beta-2, the compounds are therapeutically useful in treating conditions associated with diabetes mellitus and its complications, as well as other disease states associated with an elevation of the beta-1 and beta-2 isozyme.</p> |
| 申请公布号 |
EP1449529(A1) |
申请公布日期 |
2004.08.25 |
| 申请号 |
EP20040102054 |
申请日期 |
1994.12.14 |
| 申请人 |
ELI LILLY AND COMPANY |
发明人 |
HEATH, WILLIAM FRANCIS HEATH JUNIOR;MCDONALD, JOHN HAMPTON III;PAAL, MICHAEL;RUHTER, GERD;THEO, SCHOTTEN;STENZEL, WOLFGANG |
| 分类号 |
A61K31/40;C07D487/04;A61K31/4025;A61K31/404;A61K31/437;A61K31/44;A61K31/445;A61K31/454;A61K31/55;A61K31/70;A61K31/7056;A61P3/10;A61P7/02;A61P9/00;A61P9/10;A61P9/12;A61P17/00;A61P17/06;A61P25/00;A61P25/28;A61P29/00;A61P35/00;A61P43/00;C07D209/00;C07D221/00;C07D223/00;C07D401/14;C07D403/04;C07D403/14;C07D405/04;C07D405/14;C07D471/04;C07H15/26;(IPC1-7):A61K31/40 |
主分类号 |
A61K31/40 |
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