| 摘要 |
Compounds of formula (I) (see formula I) useful for inhibiting Ras function and therefore inhibiting or treating the abnormal growth of cells are disclosed, or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof, wherein: R and R2 are independently selected from halo; R1 and R3 are independently selected from the group consisting of H and halo, provided that at least one of R1 and R3 is H; R4 is formula (II) or R5; R5 is formula (III) (see formula III), (IV) (see formula IV), (V) (see formula V), (VI) (see formula VI), (VII) (see formula VII), (VIII) (see formula VIII), (IX) (see formula IX), (X) (see formula X) or (XI) (see formula XI); and the remaining variables are as defined in the specification.
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