发明名称 |
Sequence and method for genetic engineering of proteins with cell membrane translocating activity |
摘要 |
The invention describes a membrane-translocating peptide sequence (MTS) which facilitates entry of polypeptides and proteins into cells. Also described is an isolated nucleotide sequence encoding the membrane-translocating peptide and a method of using this sequence to genetically engineer proteins with cell membrane permeability. The MTS, and the method of genetically engineering proteins with cell membrane permeability, are useful for polypeptide and protein delivery for human and veterinary applications such as vaccine delivery and cancer therapy.
|
申请公布号 |
US6780843(B2) |
申请公布日期 |
2004.08.24 |
申请号 |
US20020116288 |
申请日期 |
2002.04.04 |
申请人 |
VANDERBILT UNIVERSITY |
发明人 |
LIN YAO-ZHONG;DONAHUE JOHN P.;ROJAS MAURICIO;TAN ZHONGJIA |
分类号 |
A61K38/00;C07K7/06;C07K7/08;C12N9/10;(IPC1-7):A61K38/04;C07K14/00 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|