| 摘要 |
A method for treating an addiction disorder (such as an addiction to or dependency on stimulants, nicotine, morphine, heroin, other opiates, amphetamines, cocaine, and/or alcohol) in a patient is disclosed. The method includes administering to the patient a first alpha3beta4 nicotinic receptor antagonist and administering to the patient a second alpha3beta4 nicotinic receptor antagonist. The second alpha3beta4 nicotinic receptor antagonist is different than the first alpha3beta4 nicotinic receptor antagonist, and the first alpha3beta4 nicotinic receptor antagonist and the second alpha3beta4 nicotinic receptor antagonist are administered simultaneously or non-simultaneously. Compositions which include a first alpha3beta4 nicotinic receptor antagonist and a second alpha3beta4 nicotinic receptor antagonist are also described. Examples of suitable alpha3beta4 nicotinic receptor antagonists for use in the present invention's methods and compositions include mecamylamine, 18-methoxycoronaridine, bupropion, dextromethorphan, dextrorphan, and phamaceutically acceptable salts and solvates thereof. A method of evaluating a compound for its effectiveness in treating addiction disorders is also described.
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