| 发明名称 |
Modified factor VIII cDNA and its use for the production of factor VIII |
| 摘要 |
A modified Factor VIII cDNA is disclosed wherein the B-domain of the wild type factor cDNA has been deleted and a truncated Factor IX intron 1 has been inserted in two locations of the Factor VIII cDNA and as a promoter a cDNA is used which is suitable for the expression in hematopoietic cell lines and specifically in platelets.
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| 申请公布号 |
US6780614(B2) |
申请公布日期 |
2004.08.24 |
| 申请号 |
US20020067894 |
申请日期 |
2002.02.08 |
| 申请人 |
AVENTIS BEHRING GMBH |
发明人 |
NEGRIER CLAUDE;PLANTIER JEAN-LUC |
| 分类号 |
C12N15/09;A61K38/00;C07K14/755;C12N15/12;C12N15/63;C12P21/02;C12P21/04;(IPC1-7):C12N15/00;C07H21/04;C07K1/00 |
主分类号 |
C12N15/09 |
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