| 摘要 |
The following compounds useful as VEGF receptor antagonists and having excellent physical properties are provided. <??>A carboxylic acid derivative represented by formula: <CHEM> wherein ring A represents a benzene ring, a naphthalene ring, or the like; W represents a C1-5 alkylene group; Z represents a single bond or a phenylene group; R<1> and R<2> are the same or different and each represents a hydrogen atom, a halogen atom, a C1-5 alkyl group or a C1-10 alkoxy group; R<3> represents a hydrogen atom, a halogen atom, a C1-12 alkyl group, a C2-5 alkynyl group, a trifluoromethyl group, an acetynyl group, a cyano group, a nitro group, -CH2-R<6>, -Y-R<11>, or the like; R<4> represents a group represented by formula: <CHEM> and R<5> represents a hydrogen atom or a C1-5 alkyl group, or a pharmaceutical acceptable salt of the derivative.
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