发明名称 BENZOTHIAZOLE DERIVATIVES.
摘要 <p>The present invention relates to compounds of the general formula (I) wherein R1 is hydrogen or lower alkyl; R2 is lower alkyl, -(CH2)n-O-lower alkyl, -C3-6-cycloalkyl or -(CH2)n-NR'2; R' is hydrogen, lower alkyl or -(CH2)n-O-lower alkyl, independently from each other for R'2, or R'2 may form together with the N atom a pyrrolidine ring; n is l, 2 or 3; and to pharmaceutically acceptable acid addition salts thereof. It has surprisingly been found that the compounds of general formula I are adenosine receptor ligands. Specifically, the compounds of the present invention have a good affinity to the A2A-receptor and they are therefore useful in the treatment of diseases, related to this receptor.</p>
申请公布号 MXPA04005077(A) 申请公布日期 2004.08.19
申请号 MX2004PA05077 申请日期 2002.11.21
申请人 F. HOFFMANN-LA ROCHE AG 发明人 ROGER DAVID NORCROSS
分类号 A61K31/428;A61K31/5377;A61P9/00;A61P9/04;A61P9/10;A61P11/00;A61P11/06;A61P21/02;A61P25/00;A61P25/02;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P25/36;A61P29/00;A61P37/08;A61P43/00;C07D277/82;C07D417/12;(IPC1-7):C07D277/82 主分类号 A61K31/428
代理机构 代理人
主权项
地址