Monoclonal antibodies specific for latent antithrombin III and the use thereof

摘要

The present invention provides antibodies that are specific for the latent or locked form of antithrombin III (AT III). The antibodies have a specificity for latent antithrombin III (1-AT III) that is higher than the specificity for natural AT III. The invention also provides methods of making and 1-AT III. It further provides methods of detecting and quantitating 1-AT III in biological samples.