发明名称 |
Prodrugs of thrombin inhibitors |
摘要 |
There is provided compounds of formula I, R<1>O(O)C-CH2-(R)Cgl-Aze-Pab-R<2> I wherein R<1 >and R<2 >have meanings given in the description, which are useful as prodrugs of inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (eg thrombosis) or as anticoagulants. |
申请公布号 |
US2004162410(A1) |
申请公布日期 |
2004.08.19 |
申请号 |
US20040776245 |
申请日期 |
2004.02.12 |
申请人 |
ASTRAZENECA AB |
发明人 |
ANTONSSON THOMAS;GUSTAFSSON DAVID;HOFFMANN KURT-JURGEN;NYSTROM JAN-ERIK;SORENSEN HENRIK;SELLEN MIKAEL |
分类号 |
A61K38/55;A61K;A61K31/00;A61K38/00;A61K38/05;A61P7/00;A61P7/02;A61P9/10;A61P43/00;C07D487/04;C07D491/04;C07D495/04;C07K;C07K1/02;C07K5/00;C07K5/02;C07K5/06;C07K5/065;C12N9/99;(IPC1-7):C07K5/06 |
主分类号 |
A61K38/55 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|