CONSTRAINED HIV V3 LOOP PEPTIDES AS NOVEL IMMUNOGENS AND RECEPTOR ANTAGONISTS
摘要
The present invention provides constrained peptides and other organic molecules, that mimic the three dimensional characteristics of the HIV-1 V3 loop peptide when bound by a highly potent human neutralizing monoclonal antibody specific for a V3 conformational epitope, which structure is determined by NMR. Methods for screening for, and designing such molecules are disclosed. These molecules are useful as immnuogens for inducing broadly-neutralizing antibodies against HIV-1 as well as antagonists for inhibiting the binding of HIV-1 to the relevant co-receptors, and may therefore be used in method of preventing or treating HIV-1 infection and disease.
申请公布号
WO2004069863(A2)
申请公布日期
2004.08.19
申请号
WO2004US03304
申请日期
2004.02.04
申请人
NEW YORK UNIVERSITY;YEDA RESEARCH AND DEVELOPMENT CO., LTD.;ANGLISTER, JACOB;SHARON, MICHAL;SCHAPIRA, MATTHIEU;ZOLLA-PAZNER, SUSAN;ROSEN, OSNAT