SYNTHESIS OF <13>C-LABELLED ESTROGEN ANALOGUES

摘要

There is provided a method of producing novel <13>C-labelled estrogen analogues. The method preferably proceeds via an intermediate A or B or which is a mixture of (A) or (B): wherein a <13>C atom is located at one or more of positions 1, 2, 3 or 4 and wherein R is an optionally substituted alkane, alkene, alkyne or aryl group. Preferably R is -CH2Ph. An alternative preferred intermediate compound is <13>C-resorcinol.