发明名称 |
DEPROTECTION OF SYNTHETIC OLIGONUCLEOTIDES USING ACRYLONITRILE SCAVENGER. |
摘要 |
<p>The present invention relates to a method of preventing modification of a synthetic oligonucleotide or oligonucleotide analog during removal of at least one bgr;-cyanoethyl protecting group from the oligonucleotide or oligonucleotide analog. The method involves contacting the oligonucleotide or oligonucleotide analog with a basic solution having at least one acrylonitrile scavenger, such as t-butylamine, at a sufficient temperature and for a sufficient period of time to remove at least one bgr;-cyanoethyl protecting group. The present invention also relates to a method of producing a synthetic oligonucleotide or oligonucleotide analog.</p> |
申请公布号 |
MXPA02012216(A) |
申请公布日期 |
2004.08.19 |
申请号 |
MX2002PA12216 |
申请日期 |
2001.06.12 |
申请人 |
AVECIA BIOTECHNOLOGY, INC. |
发明人 |
SINHA, NANDA, DULAL |
分类号 |
C07H21/04;C07H1/06;C07H21/00;(IPC1-7):C07H1/06 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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