摘要 |
The invention describes novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one COX-2 selective inhibitor, optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor, and/or, optionally, at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors. |
申请人 |
NITROMED, INC.;BANDARAGE, UPUL, K.;EARL, RICHARD, A.;EZAWA, MAIKO;FANG, XINQIN;GARVEY, DAVID, S.;KHANAPURE, SUBHASH, P.;RANATUNGE, RAMANI, R.;RICHARDSON, STEWART, K.;SCHROEDER, JOSEPH, D.;STEVENSON, CHERI, A.;WEY, SHIOW-JYI |
发明人 |
BANDARAGE, UPUL, K.;EARL, RICHARD, A.;EZAWA, MAIKO;FANG, XINQIN;GARVEY, DAVID, S.;KHANAPURE, SUBHASH, P.;RANATUNGE, RAMANI, R.;RICHARDSON, STEWART, K.;SCHROEDER, JOSEPH, D.;STEVENSON, CHERI, A.;WEY, SHIOW-JYI |