ACTIVE IMMUNIZATION TO GENERATE ANTIBODIES TO SOLUBLE A-BETA
摘要
The invention provides methods useful for effecting prophylaxis or treatment of Alzheimer's disease. Such methods entail administering A-beta fragments from a central or C-terminal regions of A-beta. Such fragments can induce a polyclonal mixture of antibodies that specifically bind to soluble A-beta without binding to plaques. The antibodies can inhibit formation of amyloid deposits of A-beta in the brain of a patient from soluble Abeta thus preventing or treating the disease. Fragment A-beta 15-24 and subfragments of 5-10 contiguous amino acids thereof are preferred immunogens due to their capacity to generate a high titer of antibodies.
申请公布号
WO2004069182(A2)
申请公布日期
2004.08.19
申请号
WO2004US02856
申请日期
2004.01.31
申请人
NEURALAB LIMITED;WYETH;YEDNOCK, TED;VASQUEZ, NICKI;BARD, FREDERIQUE;SEUBERT, PETER, A.