发明名称 |
Applications with and methods for producing selected interstrand cross-links in nucleic acids |
摘要 |
The invention relates to a method for distinguishing at least two target bio-organic molecules with dyes selected from a pool of at least two dyes, the method comprising: (a) providing a first set of at least two probes, wherein each probe recognizes a target bio-organic molecule in a first set of target bio-organic molecules, and wherein each probe is distinctly-labelled with primary labels that are distinct from one another due to the presence of dyes in distinct ratios; (b) providing a second set of probes distinctly-labelled with said primary labels described in step (a), wherein each probe in said second probe set recognizes a target bio-organic molecule in a second set of target bio-organic molecules; wherein each probe in said first or second probe set is further labelled with the same first binary label, wherein said first binary label is distinct from said primary labels; and (c) contacting said at least two target bio-organic molecules with said probe sets, wherein said target bio-organic molecules are distinguished.
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申请公布号 |
US2004161743(A1) |
申请公布日期 |
2004.08.19 |
申请号 |
US20010005371 |
申请日期 |
2001.12.05 |
申请人 |
VOLKERS HERMAN;HEETEBRIJ ROBERT;HOUTHOFF HENDRIK-JAN;VAN GIJLSWIJK R.P.M.;TANKE HENDRIKUS JOHANNES;RAAP ANTON KLAAS |
发明人 |
VOLKERS HERMAN;HEETEBRIJ ROBERT;HOUTHOFF HENDRIK-JAN;VAN GIJLSWIJK R.P.M.;TANKE HENDRIKUS JOHANNES;RAAP ANTON KLAAS |
分类号 |
G01N33/50;C07K1/13;C12N15/09;C12Q1/68;G01N33/53;G01N33/566;G01N33/58;(IPC1-7):C12Q1/68 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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