发明名称 |
METHOD FOR PRODUCING 4-(HETEROARYL-METHYL)-1(2H)-PHTHALAZINONES |
摘要 |
<p>A process for the production of 4-(heteroaryl-methyl)-halogen-1(2H)-phthalazinones, especially 4-(4-pyridylmethyl)-1(2H)-phthalazinone, is described, which is characterized by the reaction of phthalidyl-3-triphenylphosphonium salt with 4-pyridine aldehyde in the presence of a basic adjuvant, subsequent reaction with hydrazine hydrate and subsequent acid treatment, whereby this process avoids the technical safety and environmental problems of the known processes.</p> |
申请公布号 |
EP1242405(B1) |
申请公布日期 |
2004.08.18 |
申请号 |
EP20000983354 |
申请日期 |
2000.12.20 |
申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
PETROV, ORLIN;HEINER, THOMAS;NEH, HARRIBERT;KRUEGER, MARTIN |
分类号 |
C07D401/06;C07D403/06;(IPC1-7):C07D401/06 |
主分类号 |
C07D401/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|