| 发明名称 |
Protein tyrosine phosphatase 1B (PTP-1B) inhibitors containing two ortho-substituted aromatic phosphonates |
| 摘要 |
The invention encompasses the novel class of compounds represented by formula I, which are inhibitors of the PTP-1B enzyme.The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
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| 申请公布号 |
US6777433(B2) |
申请公布日期 |
2004.08.17 |
| 申请号 |
US20020185170 |
申请日期 |
2002.06.28 |
| 申请人 |
MERCK FROSST CANADA & CO. |
发明人 |
LEBLANC YVES;DUFRESNE CLAUDE;GAUTHIER JACQUES YVES;YOUNG ROBERT |
| 分类号 |
C07F9/38;(IPC1-7):A61K31/425;A61K31/40;C07D517/00;C07D271/06;C07D249/16 |
主分类号 |
C07F9/38 |
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