Use of acylated glycerols and their nitrogen and sulfur analogs for the prevention and treatment of neurodegenerative disorders, e.g. Parkinson's disease

摘要

The use of acylated glycerols, and their nitrogen and sulfur analogs (I), their optical and geometric isomers, racemates, salts, hydrates, and mixtures, for the prevention and treatment of neurodegenerative disorders. The use of acylated glycerols, and their nitrogen and sulfur analogs (I), their optical and geometric isomers, racemates, salts, hydrates, and mixtures, for the prevention and treatment of neurodegenerative disorders. [Image] G1O or N-R; G2, G3O, S, N-R4, with the proviso that G1, G2, and G3 may not simultaneously represent N-R or N-R4; R, R4H or optionally substituted, optionally unsaturated 1-5C alkyl; R1, R2, R3H, CO-R5, CO-(CH2)2n+1-X-R6, with the proviso that at least one is CO-(CH2)2n+1-X-R6; R5optionally substituted, optionally unsaturated, optionally cyclic alkyl having 1-25 C atoms in the main chain; R6optionally substituted, optionally unsaturated, optionally cyclic alkyl having 3-23 C atoms in the main chain and optionally containing one or more hetero groups selected from O, S, Se, SO and SO2; X : S, Se, SO, or SO2; n : 0-11. ACTIVITY : Antiparkinsonian; Nootropic; Neuroprotective. MECHANISM OF ACTION : Alpha Peroxisome Proliferator-Activated Receptor (PPARalpha ) Agonist.