| 摘要 |
<p>Peroxisome Proliferator-Activated Receptor (PPAR) modulators (I), their optical and geometric isomers, and their salts are new. Peroxisome Proliferator-Activated Receptor (PPAR) modulators of formula (I), their optical and geometric isomers, and their salts are new. [Image] Ar1 : an optionally substituted phenyl, pyridine, pyrazine, pyridazine, or pyrimidine; Z : a group para to X in ring Ar1 and of formula -CH2-CO-Y-R1; Ar2 : an optionally substituted phenyl, pyridine, pyrazine, pyridazine, pyrimidine or ring of formula (k) - (n); R1 : H, 1-12C alkyl, aryl, heteroaryl, aralkyl, polyether, monohydroxy alkyl, or polyhydroxy alkyl; R2 : H, 1-12C alkyl, aryl, heteroaryl, aralkyl, polyether, monohydroxy alkyl, polyhydroxy alkyl, COR5 or CSR5; Y : O, S or NR4; R4 : H, 1-12C alkyl, aryl, heteroaryl, aralkyl, polyether, or together with R1 and the N atom of Y forms a heterocycle or heteroaryl group; R5 : 1-12C alkyl, aryl, heteroaryl, aralkyl, polyether, alkoxy, monohydroxy alkyl, or polyhydroxy alkyl, R6-N-R7 or O-R8; R6, R7 : H, 1-12C alkyl, aryl, heteroaryl, aralkyl, polyether, monohydroxy alkyl, or polyhydroxy alkyl, or taken together they form a heterocycle; R8 : H, 1-12C alkyl, aryl, heteroaryl, aralkyl, polyether, monohydroxy alkyl, or polyhydroxy alkyl; X : S, SO, SO2, Se, O, NR9, CO, HO-CR11, or R10-C-R11; R9 : H, COR12, 1-12C alkyl, polyether, aryl, or aralkyl; R10, R11 : H, 1-12C alkyl, aryl, heteroaryl, aralkyl, alkoxy, polyether, monohydroxy alkyl, polyhydroxy alkyl, or taken together form a ring that may be interrupted by hetero atoms; A : S, O, Se, or NR13; R12 : 1-12C alkyl; R13 : H, 1-12C alkyl, aryl, heteroaryl, aralkyl, or polyether. ACTIVITY : Dermatological; Antiseborrheic; Antiinflammatory; Cytostatic; Antidiabetic; Hypotensive; Anorectic; Antilipemic; Antiarteriosclerotic. MECHANISM OF ACTION : Peroxisome Proliferator-Activated Receptor (PPAR) modulators.</p> |
