BICYCLISCHE HETEROAROMATISCHE VERBINDUNGEN ALS PROTEIN TYROSINE KINASE INHIBITOREN

摘要

Compounds of formula (I) and salts or solvates thereof are disclosed wherein Y is CR<1> and V is N; or Y is CR<1> and V is CR<2>; R<1> represents CH3SO2CH2CH2NHCH2-Ar-, wherein Ar is furan or thiazole, each of which may optionally be substituted by one or two halo, C1-4 alkyl or C1-4 alkoxy groups; R<2> is hydrogen C1-4 alkoxy or halo; R<3> is benzyl, halo-, dihalo- or trihalobenzyl, benzoyl, pyridylmethyl, pyridylmethoxy, phenoxy, benzyloxy, halo-, dihalo- or trihalobenzyloxy or benzenesulphonyl; R<4> is halo or C1-4 alkoxy or is not present; and wherein either (a) R<3> represents 3-fluorobenzyloxy; and/or (b) R<4> is halo and is substituted in the 3-position of the phenyl ring; and wherein halo represents fluoro, chloro or bromo. Processes for the preparation of the compounds, pharmaceutical formulations of the compounds, the use of the compounds in therapy, and methods of treatment of inter alia cancer and malignant tumours by administration of the compounds is also disclosed.