摘要 |
Compounds of formula (I) and (II) are provided wherein: X is an alkali metal or a basic amine moiety; R1 is alkyl, cycloalkyl, -CH2-cycloalkyl, pyridinyl, -CH2-pyridinyl, phenyl or benzyl, the rings of these groups being optionally substituted; R2 is H, halogen, alkyl, perfluoroalkyl, alkoxy, cycloalkyl, -CH2-cycloalkyl, -NH2, or -NO2; R3 is phenyl, benzyl, benzyloxy, pyridinyl, or -CH2-pyridinyl, with the rings of these groups being optionally substituted; or a pharmaceutically acceptable salt or ester form thereof, as well as pharmaceutical compositions and methods using these compounds as inhibitors of plasminogen activator inhibitor-1 (PAI-1) and as therapeutic compositions for treating conditions resulting from fibrinolytic disorders such as deep vein thrombosis and coronary heart disease, and pulmonary fibrosis. |
申请人 |
WYETH;ELOKDAH, HASSAN, MAHMOUD;LI, DAVID, ZENAN |
发明人 |
ELOKDAH, HASSAN, MAHMOUD;LI, DAVID, ZENAN |