发明名称 |
Production of 5-alkoxyoxazoles useful as vitamin B6 intermediates comprises heating an alpha-isocyano alkanoate ester in the presence of a high molecular weight amine |
摘要 |
Production of 5-alkoxyoxazoles (I) comprises heating an alpha -isocyano alkanoate ester (II) at a temperature above 80 [deg] C in the presence of an tertiary amine with a molecular weight above 185. Production of 5-alkoxyoxazoles of formula (I) comprises heating an alpha -isocyano alkanoate ester of formula (II) at a temperature above 80 [deg] C in the presence of an amine of formula NR5R6R7 with a molecular weight above 185. [Image] R1optionally substituted 1-6C alkyl; R2H or optionally substituted 1-6C alkyl; R5-R7optionally substituted 1-9C alkyl or 5-7C cycloalkyl; or two of R5-R7optionally substituted (un)saturated heterocycle. An independent claim is also included for production of pyridoxine derivatives of formula (IX) by: (1) esterifying an amino acid of formula (III); (2) converting the ester to a N-formyl derivative of formula (V); (3) converting this to (II) and thence to (I) as above; (4) reacting (I) with a protected diol of formula (VI) to form a Diels-Alder adduct of formula (VII); and (5) converting this to (IX) by acid treatment and deprotection. [Image] R3, R4protecting groups. |
申请公布号 |
DE10304343(A1) |
申请公布日期 |
2004.08.12 |
申请号 |
DE2003104343 |
申请日期 |
2003.02.03 |
申请人 |
BASF AG |
发明人 |
ARNDT, JAN-DIRK;HENKELMANN, JOCHEM;BURKART, KIRSTEN;HEIMANN, FRANK;RUST, HARALD;BECKER, MICHAEL |
分类号 |
C07D213/67;C07D263/42 |
主分类号 |
C07D213/67 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|