DESIGN AND SYNTHESIS OF RENAL DIPEPTIDASE INHIBITORS
摘要
Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity. These compounds can be used therapeutically and diagnostically for treatment and detection of tumors.
申请公布号
WO2004010846(A3)
申请公布日期
2004.08.12
申请号
WO2003US23363
申请日期
2003.07.28
申请人
THE JOHNS HOPKINS SCHOOL OF MEDICINE;KHAN, SAEED, R.;VOGELSTEIN, BERT;KINZLER, KENNETH, W.;GURULINGAPPA, HALLUR;BUCKHAULTS, PHILLIP
发明人
KHAN, SAEED, R.;VOGELSTEIN, BERT;KINZLER, KENNETH, W.;GURULINGAPPA, HALLUR;BUCKHAULTS, PHILLIP