| 摘要 |
PROBLEM TO BE SOLVED: To provide a number of different compositions and methods which share the common feature of having gene expression regulated by tet operator/repressor system. SOLUTION: Disclosed is a recombinant protein formed with a host cell obtained by transfecting with a recombinantly engineered virus, wherein the virus comprises within its genome (a) a recombinant promoter having a TATA element, (b) at least one tet operator sequence beginning at least 6 nucleotides or their downstream from the last nucleotide in the TATA element, and (c) a gene lying 3' to the operator and operably linked to the promoter, wherein the gene inhibits the replication of the virus when expressed. COPYRIGHT: (C)2004,JPO&NCIPI
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